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Friday, July 18, 2008
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Imaging Advance Tracks Prostate Cancer in Lymph Nodes
Imaging Advance Tracks Prostate Cancer in Lymph Nodes
HealthDay
By HealthDay staff
Tuesday, July 15, 2008TUESDAY, July 15 (HealthDay News) -- A new imaging technique, based on an engineered version of the common cold virus, may help doctors detect the spread of prostate cancer to the lymph nodes earlier.
This, in turn, could help guide more effective treatment decisions, said the authors of a study published in the July 11 edition of Nature Medicine.
"It would represent a treatment advance in patients for whom outcome is not good," study senior author Dr. Lily Wu, a researcher at UCLA's Jonsson Cancer Center, said in a university news release. "This would help improve the prognosis for these patients by letting us find and treat these metastases early. If we can catch the cancer before it invades other organs, we have a better chance to change the outcomes for these patients."
Patients whose prostate cancer has traveled to their lymph nodes are more likely to have a recurrence. Finding these tiny metastases in the pelvic lymph nodes is key to making future treatment decisions, yet it is also supremely difficult to do with conventional imaging techniques.
Wu and her colleagues engineered a common cold virus armed with a specific "genetic payload" to travel directly to lymph nodes in mice and to express its payload only in prostate cells.
The payload consists of a protein that can be picked up on PET scans.
Wu and her colleagues next want to combine the imaging technique with treatment, so that a drug contained in the genetic payload could kill the traveling tumor cells.
"I think this is very exciting for many reasons," said Wu. "We now know we can reach these prostate cancer metastases at an earlier stage than before, and we know we can deliver genes to those cancer cells that produce proteins that can be imaged by PET. Now we will find out how effective this genetic toxic payload is in preventing further spread of the cancer to other vital organs."
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Men, masculine identities, and health care utilisation.
Men, masculine identities, and health care utilisation.
Sociol Health Illn. 2008 Jun 18Noone JH, Stephens C.Department of Psychology, Massey University, New Zealand.
Seeking medical help early is critical for recovery, yet evidence indicates that men do not utilise general practitioner services as often as women. This paper draws on Connell's (1995) theory of hegemonic masculinity to critically examine how men's under-utilisation of medical services may be influenced by the social construction of masculine identities. Interviews with seven older rural men about their help-seeking behaviour, used a movie extract and hypothetical scenarios to stimulate discussion. Transcribed data were analysed using discourse analysis, which showed that in this particular social context, the men faced a dilemma when identifying with two conflicting subject positions: the virtuous regular health care user, and the masculine infrequent user of health care services. They solved this dilemma by positioning women as frequent and trivial users of health care and themselves as legitimate users of health care. By using biomedical and morality discourses in this way the men could maintain a masculine identity whilst also identifying as virtuous users of health care services. These results support the utility of hegemonic masculinity as a theoretical basis for examining the construction and maintenance of gendered identities by highlighting the complexity of multiple masculine identities.
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Men's health promotion: A new frontier in Australia and the UK?
Men's health promotion: A new frontier in Australia and the UK?
Health Promot Int. 2008 Jul Smith JA, Robertson S.1Department of Paramedic and Social Health Sciences, School of Medicine, Flinders University, Adelaide, South Australia, Australia.
The field of men's health has grown markedly over the past few decades. Increased activity specifically relating to men's health promotion in both Australia and the UK has been noted during this period. There has, however, been a reticence to critically examine men's health promotion work within a broader discourse relating to gender and gender relations. Indeed, the vast majority of health-related gender discussion to date has been focused on women's health experiences and their health practices. In this paper, we argue that grounding men's health within this broad gender discourse is important for building an evidence base in, and advancing, men's health promotion work at a range of levels. We specifically explore the research, practice and policy contexts relating to men's health in Australia and the UK, and describe the facilitators for, and barriers to, promoting men's health. We conclude by suggesting that a critical gender lens ought to be applied to current men's health promotion work and provide strategies for researchers, practitioners and policy makers to move towards this new frontier.
Wednesday, May 14, 2008
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What Are Overweight and Obesity?
What Are Overweight and Obesity?
The terms “overweight” and “obesity” refer to a person’s overall body weight and where the extra weight comes from. Overweight is having extra body weight from muscle, bone, fat, and/or water. Obesity is having a high amount of extra body fat. The most useful measure of overweight and obesity is the body mass index (BMI). BMI is based on height and weight and is used for adults, children, and teens. For more information about BMI, see “How Are Overweight and Obesity Diagnosed?”
Millions of Americans and people worldwide are overweight or obese. Being overweight or obese puts you at risk for many diseases and conditions. The more body fat that you carry around and the more you weigh, the more likely you are to develop heart disease, high blood pressure, type 2 diabetes, gallstones, breathing problems, and certain cancers.
A person’s weight is a result of many factors. These factors include environment, family history and genetics, metabolism (the way your body changes food and oxygen into energy), behavior or habits, and other factors.
Certain things, like family history, can’t be changed. However, other things—like a person’s lifestyle habits—can be changed. You can help prevent or treat overweight and obesity if you:
- Follow a healthful diet, while keeping your calorie needs in mind
- Are physically active
- Limit the time you spend being physically inactive
Weight loss medicines and surgery also are options for some people who need to lose weight if lifestyle changes don’t work.
Outlook
Reaching and staying at a healthy weight is a long-term challenge for people who are overweight or obese. But it also can be a chance to lower your risk of other serious health problems. With the right treatment and motivation, it’s possible to lose weight and lower your long-term disease risk.
What Causes Overweight and Obesity?
Energy Balance
For most people, overweight and obesity are caused by not having energy balance. Weight is balanced by the amount of energy or calories you get from food and drinks (this is called energy IN) equaling the energy your body uses for things like breathing, digesting, and being physically active (this is called energy OUT).
Energy balance means that your energy IN equals your energy OUT. To maintain a healthy weight, your energy IN and OUT don’t have to balance exactly every day. It’s the balance over time that helps you maintain a healthy weight.
- The same amount of energy IN and energy OUT over time = weight stays the same
- More IN than OUT over time = weight gain
- More OUT than IN over time = weight loss
Overweight and obesity happen over time when you take in more calories than you use.
Other Causes
Physical Inactivity
Many Americans aren’t very physically active. There are many reasons for this. One reason is that many people spend hours in front of TVs and computers doing work, schoolwork, and leisure activities. In fact, more than 2 hours a day of regular TV viewing time has been linked to overweight and obesity.
Other reasons for not being active include: relying on cars instead of walking to places, fewer physical demands at work or at home because modern technology and conveniences reduce the need to burn calories, and lack of physical education classes in schools for children.
People who are inactive are more likely to gain weight because they don’t burn up the calories that they take in from food and drinks. An inactive lifestyle also raises your risk for heart disease, high blood pressure, diabetes, colon cancer, and other health problems.
Environment
Our environment doesn’t always help with healthy lifestyle habits; in fact, it encourages obesity. Some reasons include:
- Lack of neighborhood sidewalks and safe places for recreation. Not having area parks, trails, sidewalks, and affordable gyms makes it hard for people to be physically active.
- Work schedules. People often say that they don’t have time to be physically active given the long hours at work and the time spent commuting back and forth to work.
- Oversized food portions. Americans are surrounded by huge food portions in restaurants, fast food places, gas stations, movie theaters, supermarkets, and even home. Some of these meals and snacks can feed two or more people. Eating large portions means too much energy IN. Over time, this will cause weight gain if it isn’t balanced with physical activity.
- Lack of access to healthy foods. Some people don’t live in neighborhoods that have supermarkets that sell healthy foods such as fresh fruits and vegetables. Or if they do, these items are often too costly.
- Food advertising. Americans are surrounded by ads from food companies. Often children are the targets of advertising for high-calorie, high-fat snacks and sugary drinks. The goal of these ads is to sway people to buy these high-calorie foods, and often they do.
Genes and Family History
Studies of identical twins who have been raised apart show that genes have a strong influence on one’s weight. Overweight and obesity tend to run in families. Your chances of being overweight are greater if one or both of your parents are overweight or obese. Your genes also may affect the amount of fat you store in your body and where on your body you carry the extra fat.
Because families also share food and physical activity habits, there is a link between genes and the environment. Children adopt the habits of their parents. So, a child with overweight parents who eat high-calorie foods and are inactive will likely become overweight like the parents. On the other hand, if a family adopts healthful food and physical activity habits, the child’s chance of being overweight or obese is reduced.
Health Conditions
Sometimes hormone problems cause overweight and obesity. These problems include:
- Underactive thyroid (also called hypothyroidism). This is a condition in which the thyroid gland doesn’t make enough thyroid hormone. Lack of thyroid hormone will slow down your metabolism and cause weight gain. You’ll also feel tired and weak.
- Cushing’s syndrome. This is a condition in which the body’s adrenal glands make too much of the hormone cortisol. Cushing’s syndrome also can happen when people take high levels of medicines such as prednisone for long periods of time. People with Cushing’s syndrome gain weight, have upper-body obesity, a rounded face, fat around the neck, and thin arms and legs.
- Polycystic ovarian syndrome (PCOS). This is a condition that affects about 5 to 10 percent of women of childbearing age. Women with PCOS often are obese, have excess hair growth, and have reproductive and other health problems due to high levels of hormones called androgens.
Medicines
Certain medicines such as corticosteroids (for example, prednisone), antidepressants (for example, Elavil®), and medicines for seizures (for example, Neurontin®) may cause you to gain weight. These medicines can slow the rate at which your body burns calories, increase your appetite, or cause your body to hold on to extra water—all of which can lead to weight gain.
Emotional Factors
Some people eat more than usual when they are bored, angry, or stressed. Over time, overeating will lead to weight gain and may cause overweight or obesity.
Smoking
Some people gain weight when they stop smoking. One reason is that food often tastes and smells better. Another reason is because nicotine raises the rate at which your body burns calories, so you burn fewer calories when you stop smoking. However, smoking is a serious health risk, and quitting is more important than possible weight gain.
Age
As you get older, you tend to lose muscle, especially if you’re less active. Muscle loss can slow down the rate at which your body burns calories. If you don’t reduce your calorie intake as you get older, you may gain weight. Midlife weight gain in women is mainly due to aging and lifestyle, but menopause also plays a role. Many women gain around 5 pounds during menopause and have more fat around the waist than they did before.
Pregnancy
During pregnancy, women gain weight so that the baby gets proper nourishment and develops normally. After giving birth, some women find it hard to lose the weight. This may lead to overweight or obesity, especially after a few pregnancies.
Lack of Sleep
Studies find that the less people sleep, the more likely they are to be overweight or obese. People who report sleeping 5 hours a night, for example, are much more likely to become obese compared to people who sleep 7–8 hours a night.
People who sleep fewer hours also seem to prefer eating foods that are higher in calories and carbohydrates, which can lead to overeating, weight gain, and obesity over time. Hormones that are released during sleep control appetite and the body’s use of energy. For example, insulin controls the rise and fall of blood sugar levels during sleep. People who don’t get enough sleep have insulin and blood sugar levels that are similar to those in people who are likely to have diabetes.
Also, people who don’t get enough sleep on a regular basis seem to have high levels of a hormone called ghrelin (which causes hunger) and low levels of a hormone called leptin (which normally helps to curb hunger).
What Are the Health Risks of Overweight and Obesity?
Being overweight or obese isn’t a cosmetic problem. It greatly raises the risk in adults for many diseases and conditions.
Overweight and Obesity-Related Health Problems in Adults
Heart Disease
This condition occurs when a fatty material called plaque (plak) builds up on the inside walls of the coronary arteries (the arteries that supply blood and oxygen to your heart). Plaque narrows the coronary arteries, which reduces blood flow to your heart. Your chances for having heart disease and a heart attack get higher as your body mass index (BMI) increases. Obesity also can lead to congestive heart failure, a serious condition in which the heart can’t pump enough blood to meet your body’s needs.
High Blood Pressure (Hypertension)
This condition occurs when the force of the blood pushing against the walls of the arteries is too high. Your chances for having high blood pressure are greater if you’re overweight or obese.
Stroke
Being overweight or obese can lead to a buildup of fatty deposits in your arteries that form a blood clot. If the clot is close to your brain, it can block the flow of blood and oxygen and cause a stroke. The risk of having a stroke rises as BMI increases.
Type 2 Diabetes
This is a disease in which blood sugar (glucose) levels are too high. Normally, the body makes insulin to move the blood sugar into cells where it’s used. In type 2 diabetes, the cells don’t respond enough to the insulin that’s made. Diabetes is a leading cause of early death, heart disease, stroke, kidney disease, and blindness. More than 80 percent of people with type 2 diabetes are overweight.
Abnormal Blood Fats
If you’re overweight or obese, you have a greater chance of having abnormal levels of blood fats. These include high amounts of triglycerides and low-density lipoprotein (LDL) cholesterol (a fat-like substance often called “bad” cholesterol), and low high-density lipoprotein (HDL) cholesterol (often called “good” cholesterol). Abnormal levels of these blood fats are a risk for heart disease.
Metabolic Syndrome
This is the name for a group of risk factors linked to overweight and obesity that raise your chance for heart disease and other health problems such as diabetes and stroke. A person can develop any one of these risk factors by itself, but they tend to occur together. Metabolic syndrome occurs when a person has at least three of these heart disease risk factors:
- A large waistline. This is also called abdominal obesity or “having an apple shape.” Having extra fat in the waist area is a greater risk factor for heart disease than having extra fat in other parts of the body, such as on the hips.
- Abnormal blood fat levels, including high triglycerides and low HDL cholesterol.
- Higher than normal blood pressure.
- Higher than normal fasting blood sugar levels.
Cancer
Being overweight or obese raises the risk for colon, breast, endometrial, and gallbladder cancers.
Osteoarthritis
This is a common joint problem of the knees, hips, and lower back. It occurs when the tissue that protects the joints wears away. Extra weight can put more pressure and wear on joints, causing pain.
Sleep Apnea
This condition causes a person to stop breathing for short periods during sleep. A person with sleep apnea may have more fat stored around the neck. This can make the breathing airway smaller so that it’s hard to breathe.
Reproductive Problems
Obesity can cause menstrual irregularity and infertility in women.
Gallstones
These are hard pieces of stone-like material that form in the gallbladder. They’re mostly made of cholesterol and can cause abdominal or back pain. People who are overweight or obese have a greater chance of having gallstones. Also, being overweight may result in an enlarged gallbladder that may not work properly.
Overweight and Obesity-Related Health Problems in Children and Teens
Overweight and obesity also increase the health risks for children and teens. Type 2 diabetes was once rare in American children. Now it accounts for 8 to 45 percent of newly diagnosed diabetes cases. Also, overweight children are more likely to become overweight or obese as adults, with the same risks for disease.
Who Is At Risk for Overweight and Obesity?
Populations Affected
Overweight and obesity affect Americans of all ages, sexes, racial/ethnic groups, and educational levels. This serious health problem has been growing over the years. In fact, overweight and obesity in adults have doubled since 1980, and overweight in children and teens has tripled.
Adults
According to the National Health and Nutrition Examination Survey (NHANES) 2003–2004, about one-third of adults in the United States are overweight and slightly more than one-third are obese. The survey also shows differences in overweight and obesity according to racial/ethnic groups.
- In women, overweight and obesity are highest for non-Hispanic Black women (about 82 percent), compared to about 75 percent for Mexican American women and 58 percent for non-Hispanic White women.
- In men, overweight and obesity also are higher for minority groups. They’re highest for Mexican American men (about 76 percent), compared to about 71 percent for non-Hispanic White men and about 69 percent for non-Hispanic Black men.
Children and Teens
According to NHANES 2003–2004, overweight and the risk for overweight is rising in children and teens. The survey shows that:
- About 19 percent of school-aged children and about 17 percent of teens are overweight.
- About 18 percent of school-aged children and about 17 percent of teens are at risk for overweight.
There are also some differences in overweight according to racial/ethnic groups.
- In male children and teens, overweight is highest for Mexican Americans (about 22 percent), compared to 17 percent for non-Hispanic Whites and about 16 percent for non-Hispanic Blacks.
- In female children and teens, overweight is highest for non-Hispanic Blacks (23 percent), compared to 16 percent for Mexican Americans and about 14 percent for non-Hispanic Whites.
Income
Overweight and obesity are also common in groups with low incomes. Women with low incomes are about 50 percent more likely to be obese than women with higher incomes. Among children and teens, overweight in non-Hispanic White teens is related to a lower family income.
Low-income families also buy more high-calorie, high-fat foods, which may add to the problem. This is because they tend to cost less than more healthful foods such as fruits and vegetables.
What Are the Signs and Symptoms of Overweight and Obesity?
Weight gain usually happens over time. Most people know when they’ve gained weight. Some of the signs of overweight or obesity include:
- Clothes feeling tight and needing a larger size.
- The scale showing that you’ve gained weight.
- Having extra fat around the waist.
- A higher than normal body mass index and waist circumference. (See “How Are Overweight and Obesity Diagnosed?”)
Friday, November 16, 2007
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Male menopause: Myth or reality?
Male menopause: Myth or reality?
Sometimes called male menopause, aging-related hormone changes are very different in men than in women. Learn about symptoms and treatment.
Less interested in sex lately? Tired? Grumpier than usual? Is this a midlife crisis brewing? Or are you feeling the normal hormone changes associated with aging? Hormone changes are a natural part of aging for men. But male menopause is not an accurate description. Unlike the more dramatic hormone plunge that occurs in women during menopause, hormone changes in men occur gradually, over a period of many years, the effects of which are often subtle and not noticed until much later in life. Some men are never affected by lower hormone levels at all — while some have physical and psychological symptoms that can include changes in sexual function, energy levels or mood.
While the term "male menopause" is sometimes used to describe decreasing testosterone levels related to aging, Todd Nippoldt, M.D., an endocrinologist at Mayo Clinic, Rochester, Minn., prefers the term "andropause." "There needs to be a distinction because we're dealing with two different situations," he says. "In women, ovulation ceases and female hormone production plummets over a relatively short time frame. In men, there's a gradual decline in the production of male hormones." Age-related decline in testosterone levels are also called testosterone deficiency, androgen decline in the aging male (ADAM) or late onset hypogonadism (LOH).
Male hormones over time
In general, older men have lower testosterone levels than do younger men. After age 40, testosterone levels in the blood begin to decline gradually — at a rate of about 1 percent a year. While there's a steep drop between the ages of 45 and 50, reduction in testosterone levels are rarely significant enough to be noticeable in men younger than 60. By the time men reach their 80s, about half have low testosterone. But testosterone levels vary greatly among men — and some men maintain normal testosterone levels into old age. Other men who have low testosterone levels don't have bothersome signs or symptoms.
What are the symptoms of andropause?
Lower than normal testosterone levels do not cause symptoms in all men — and signs and symptoms of low testosterone vary from person to person. Some of these signs and symptoms are a normal part of aging. The only sure way to know whether you have low testosterone levels is through blood tests.
Signs and symptoms of low testosterone can include:
- Reduced sexual desire
- Infertility
- A decrease in spontaneous erections (such as during sleep)
- Swollen or tender breasts (gynecomastia)
- Loss of body and pubic hair
- Small or shrinking testes
- Height loss and thinning bones
- Reduced muscle bulk and strength
- Hot flushes and sweats
Other signs and symptoms can include:
- Decreased energy, motivation and self-confidence
- Feeling sad or depressed
- Poor concentration and memory
- Sleep apnea or other sleep problems
- A low red blood cell count (mild anemia)
- Increased body fat
- Diminished physical or work performance
Testosterone replacement therapy
Treatment of low testosterone due to aging with testosterone replacement therapy (TRT) is controversial. The benefits of TRT are not clear, and it may increase the risk of prostate cancer. While certain men who have symptoms related to abnormally low testosterone may benefit from testosterone replacement therapy, it isn't appropriate treatment for most aging men. While it has been shown to help some men with low testosterone, TRT has risks, especially for men with certain health conditions such as prostate cancer and heart disease — and it may not improve your symptoms. More studies need to be done to determine the effectiveness and safety of TRT in aging men, and who can benefit most from this type of treatment. As it turned out with hormone replacement for women, TRT may have possible long-term risks that are not yet known.
Herbal supplements: Do they work?
Although many herbal supplements are widely marketed with the claim that they can relieve symptoms, none has been proved safe and effective for aging-related low testosterone. One of the most common supplements marketed to treat this condition, DHEA, may increase the risk of prostate cancer. More studies are needed to evaluate possible health benefits — and dangers — of taking DHEA or other supplements. Talk with your doctor before taking any herbal supplements, as some can cause side effects or cause problems with medications.
Is it low testosterone — or is it something else?
Symptoms caused by testosterone deficiency are similar to symptoms caused by other things. Signs and symptoms can include:
- A number of other health problems such as liver disease, kidney failure, or an overactive or underactive thyroid
- Side effects of medications
- Lifestyle choices such as excessive alcohol use or use of illegal drugs
- Psychological conditions, such as depression or emotional distress related to life changes that come with middle age (the so-called midlife crisis)
Steps that may help
While there's no way to avoid lower testosterone levels caused by aging, there are a few things you can do to help prevent or improve symptoms caused by the condition:
- Eat right and stay active. Regular exercise and a healthy diet can help you maintain your strength, energy and lean muscle mass. It can also improve your mood and help you stay sharp as you get older.
- Talk to your doctor about sexual problems. Erectile dysfunction and other sexual issues are common as men get older. Your doctor can help you find the best way to cope. Medical treatment, lifestyle changes or changes to the dose or types of medications you take may help.
- Seek help if you feel down. Many older men suffer from depression. It often goes undiagnosed — but treatment can make a big difference in how you feel. Depression in men doesn't always mean having the blues. You may have depression if you feel irritable, isolated and withdrawn. Other signs of depression common in men include working all the time, drinking too much alcohol, using street drugs or seeking thrills from risky activities.
If you are an older man and you have bothersome symptoms you think might be caused by low testosterone, see your doctor to get a firm diagnosis and find out your treatment options. While low testosterone does cause signs and symptoms in some men, your symptoms may be caused by normal aging or something else. Identifying and treating other health issues that can cause or worsen symptoms, making lifestyle changes, or changing the type or dose of medications you take may be enough.
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About Me
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Am old enough to understand the difference between the Bay of Pigs - and roasting a pig at a epicurian feast. Been thru the hippy, yippie and yuppie years - always remaining who I am. Very much believe in "Sing your own song - weave your own tapestry" Am young enough to still know the thrill of new discoveries, the beauty of the evening, to celebrate the joy of another tommorow. Survived these many decades with a severe medical problems. Sorting out the maze of now having two lymphomas and all their nasty little companions, but I continue. Besides, being a simple iconoclastic eclectic, have been called many things. An incurable romanticist - with a strong touch of reality. Thinker, intellectual (God, how I hate that term) - been told I am a lion with the heart of the poet. Know how to wage war and conquer my foes - but would rather be known as one who brings hope and life. To bring hope into anothers life is the ultimate of joys. Life should be about bringing hope, peace, vision... a s



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